Kim JY, et al. - Authors assessed public microarray data to find the apoptosis-related genes linked with the recurrence of ameloblastomas and also to assess utility as a prognostic marker as well as a target molecule to prevent recurrence. They recorded two most upregulated genes in ameloblastoma: osteoprotegerin (OPG) and B-cell lymphoma 2 (Bcl-2). They also noticed a significant correlation between Bcl-2 expression and recurrence in the conservative treatment group. They reported an rise in apoptosis with silencing of Bcl-2 in AM-1 cells in vitro and repression of tumor nodule formation of AM-1 cells in vivo. Hence, Bcl-2 expression was concluded as a valuable biomarker to predict recurrence of ameloblastomas.