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Basophils from allergic patients are neither hyper-responsive to activation signals nor hypo-responsive to inhibition signals

The Journal of Allergy and Clinical Immunology Jan 31, 2018

Cassard L, et al. - Researchers here examined whether mechanisms that control, positively and negatively, basophil activation (which were unraveled and studied in basophils from normal donors) were functional in allergic patients. Observations revealed that regulatory mechanisms controlling basophil activation were fully functional in these patients. In these mechanisms, intrinsic defects did not explain allergic manifestation.
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