Boita M, et al. - Whether the expression of the IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) receptors on the basophil membrane are associated with asthma severity, was investigated in the present study. In patients with severe asthma, high expression of the IL-25 and IL-33 receptors on the basophil membrane was apparent, indicating an overstimulation of basophils by these cytokines in severe asthma. This finding can possibly be used as a biomarker of asthma severity.