Gamble DT, et al. - The association between anticholinergic burden (ACB) from medications and stroke in a general population was determined. To help attenuate the global burden of stroke, an incentive was offered for the cautious use of medications with anticholinergic properties. In the fully adjusted model, patients with an ACB >3 had a 59% relative risk of incident stroke and 86% relative risk of stroke mortality compared with patients in the ACB 0 category.