Solanky D, et al. - In this study, researchers examined factors predictive of progression from nondysplastic Barrett esophagus (NDBE) or low-grade dysplasia (LGD) to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) utilizing a large, prospective cohort of patients in which all esophageal biopsies undergo expert gastrointestinal pathologist review. NDBE and LGD subjects have been identified in a tertiary care center from a prospective registry. In order to identify predictors of progression, the Cox proportional hazards model were used. A total of 318 were included with NDBE and 301 with Barrett esophagus (BE)-LGD. BE length, presence of LGD, and nodularity were independent predictors of progression to HGD/EAC in this well-defined cohort of NDBE and BE-LGD subjects. These factors can help to identify patients at high risk who may benefit from closer endoscopic surveillance/therapy.