du Fay de Lavallaz J, et al. - In this prospective diagnostic multicenter study with patients >45-years old presenting with syncope to the emergency department, researchers assessed the diagnostic and prognostic accuracy of B-type natriuretic peptide (BNP), N-terminal proBNP (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), and high-sensitivity cardiac troponin I (hs-cTnI) concentrations, alone and against those of clinical evaluations. For all four biomarkers, an area under the curve of 0.77 to 0.78 was generated for diagnostic accuracy for cardiac syncope, which was superior to EGSYS (Evaluation of Guidelines in Syncope Study). With an area under the curve of 0.81, a further improved diagnostic accuracy was obtained when BNP/NT-proBNP was combined with hs-cTnT/hs-cTnI. For major adverse cardiac events, BNP, NT-proBNP, hs-cTnI, and hs-cTnT exhibited a moderate-to-good prognostic accuracy, which was superior to ROSE (Risk Stratification of Syncope in the Emergency Department), OESIL (Osservatorio Epidemiologico della Sincope nel Lazio), and SFSR (San Fransisco Syncope Rule), and inferior to CSRS (Canadian Syncope Risk Score). Overall, useful diagnostic and prognostic information can be derived via BNP, NT-proBNP, hs-cTnT, and hs-cTnI concentrations in emergency department patients with syncope.