Zhang A, et al. - Researchers here investigated whether B type natriuretic peptide (BNP) index was associated with the severity of hand-foot-mouth disease (HFMD) and the outcome in severe HFMD. As per findings, they suggested BNP as a biochemical indicator for severe (critical) HFMD and thus could be used for prognosis in terms of complications and death. Combined with Glu and partial pressure of oxygen (PaO₂)/fraction of inspired oxygen (FiO₂) and clinical symptoms of HFMD, the value of BNP as an indicator became more precise and specific. Results thereby suggested another valuable, objective biochemical indicator for severe HFMD.