Romei C, Tavanti LM, Taliani A, et al. - A retrospective study was conducted to examine the role of a quantitative analysis software (CALIPER) in distinguishing HRCT thresholds predicting IPF patients’ survival and lung function decline and its role in detecting changes of HRCT abnormalities related to treatment and their correlation with Forced Vital Capacity (FVC). A total of 105 individuals were enrolled with a multidisciplinary diagnosis of IPF for whom one HRCT at baseline and concomitant FVC were available. HRCTs were estimated with CALIPER and the relationship between FVC and radiological features were evaluated. It was reported that CALIPER quantification of fibrosis and vascular involvement could detect disease progression in treated vs untreated individuals and prognosticate the survival. The differences in CALIPER-derived variables over time were significantly correlated to changes in FVC.