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Autologous fibroblasts for vocal scars and age‐related atrophy: A randomized clinical trial

The Laryngoscope Oct 25, 2020

Ma Y, Long J, Amin MR, et al. - In this randomized, double‐blinded, placebo‐controlled, multi‐institutional, phase II trial, researchers tested the effectiveness and safety of autologous cultured fibroblasts (ACFs) to treat dysphonia related to vocal fold scar and age‐related vocal atrophy (ARVA). For this analysis, 15 patients received ACF and six received saline injections. A significant improvement in mucosal wave grade relative to baseline was observed in both vocal scar and ARVA groups at 4, 8, and 12 months after ACF treatments. In patients with vocal scar and ARVA, injection of ACFs into the vocal fold lamina propria (LP) was safe and significantly improved mucosal waves. ACF can make a commitment to reconstruct the LP.

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