Gibson FT, et al. - Using PubMed and CINAHL search engines, researchers conducted a comprehensive review of available, published literature to examine the clinical course of autoimmune blistering diseases (AIBDs) following treatment with biologic agents (BAs) for chronic inflammatory diseases. A total of 22 AIBDs cases caused by the use of BAs have been reported. Tumor necrosis factor-alpha inhibitors were the most commonly implicated agents. Data reported that the mean age of onset of AIBD was 59.4 years. Psoriasis, accompanied by rheumatoid arthritis and ulcerative colitis, was the most common associated condition for which BA was prescribed. In patients developing AIBD while being treated for chronic inflammatory diseases, BAs may be suspected. A majority of cases resolve when the offending agent is discontinued.