Cherry KD, Schwarz RA, Yang EC, et al. - Researchers focused on the utility of autofluorescence imaging (AFI), an optical modality, for helping clinicians in identifying early cancers and high-grade dysplasia among patients with oral potentially malignant disorders (OPMD). At successive clinic visits, OPMD patients undergoing monitoring for the development of oral cancer were analyzed using AFI. Two groups were defined on the basis of patients' endpoint: surveillance (n = 6) or surgery (n = 9). Before the study endpoint, high-risk for progression was clinically detected in 0/6 (0%) of patients in the surveillance group and in 9/9 (100%) patients in the surgery group, while 1/6 (17%) of patients and 8/9 (89%) of patients were at high risk for progression based on AFI during the same time period in the surveillance group and in the surgery group, respectively. In these patient groups, AFI results tracked over time were found comparable to expert clinical impression. Overall, findings are indicative of the potential of AFI as a tool to help clinicians in noninvasively monitoring oral precancer and assessing OPMDs that need increased scrutiny.