Colliard S, et al. - Authors research the presence of anti-ficolin-2 antibodies in systemic lupus erythematosus (SLE) patients and aim to assess the relationship between the levels of these autoantibodies, clinical manifestations, and disease activity. These outcomes support the usefulness of anti-ficolin-2 as a complementary serological biomarker for the diagnosis of active lupus with the renal manifestation.