Bethin KE, et al. - In this investigation involving 10,032 participants (aged < 18 years), researchers evaluated the frequency of autism spectrum disorder (ASD) in children with type 1 diabetes in the T1D Exchange (T1DX) registry and the effect of ASD on traits of children with type 1 diabetes. For 159 candidates, a diagnosis of ASD (defined as autism, Asperger's or pervasive developmental disorder) was recorded. In the T1DX registry, the frequency of ASD was comparable to that in the general population. These data indicate that in youth with and without ASD, despite communication deficits, the incidence of diabetic ketoacidosis was comparable. In those with ASD, pump use was less frequent, possibly due to sensory issues, although the use of CGM was not different. The reduced HbA1c may be due to an ASD routine that is more regimented. Because comorbidities like ASD complicate the care of type 1 diabetes patients, further research is required to support these children.