Kim MJ, et al. - Using the specific pancreatic endoplasmic reticulum kinase (PERK) inhibitors GSK2606414 and GSK2656157, the authors aimed to examine the effect of partial PERK suppression. As per the outcomes, partial PERK inhibition induced BiP expression in islets, increased glucose-stimulated calcium transit and islet insulin contents and enhanced glucose-stimulated insulin secretion (GSIS). Thus, findings suggested that low-dose PERK inhibitors could potentially be used to treat insulin deficiency.