You Y, et al. - Researchers used the Oncomine, Cancer Cell Line Encyclopedia, bc-GenExMiner, cBioPortal and Kaplan–Meier plotter databases, to assess the expression profiles of ZHX factors in breast cancer, given that ZHX family has recently been in the spotlight as an integrator and an indispensable node in carcinogenesis, whose expression is frequently dysregulated in multiple cancers. The link between ZHX3 protein expression and clinicopathological parameters and patient outcomes was assessed in 98 primary tumor samples by immunohistochemistry. Findings highlighted a possible involvement of dysregulated expression of ZHXs in the progression of breast cancer, as well as these, could be a novel biomarker and potential target for breast cancer. They found a correlation between high mRNA levels of ZHX2 and ZHX3 and better overall survival in patients with breast cancer. Poorer outcomes were seen among patients with decreased ZHX3 protein levels.