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Atrial fibrillation and outcomes after transcatheter or surgical aortic valve replacement (from the PARTNER 3 trial)

The American Journal of Cardiology Mar 14, 2021

Shahim B, Malaisrie SC, George I, et al. - Researchers aimed at determining how preexisting atrial fibrillation or flutter (AF) affects prognosis in low-risk patients with severe aortic stenosis (AS) treated with transcatheter (TAVR) or surgical aortic valve replacement (SAVR). They conducted a sub-analysis of the PARTNER 3 trial, in which patients with severe aortic stenosis at low surgical risk were randomized 1:1 to TAVR vs SAVR, for assessing the clinical outcomes of the patients at 2 years according to AF status. The analysis was performed including 948 patients [452 (47.7%) in the SAVR vs 496 (52.3%) in the TAVR arm]; of these patients, 168 (17.6%) had AF [88/452 (19.5%) and 80/496 (16.1%) treated with SAVR and TAVR, respectively]. Outcomes revealed increased risk of the composite outcome of death, stroke or rehospitalization at 2 years in correlation with preexisting AF in patients with severe AS at low surgical risk; this was noted irrespective of treatment modality.

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