Arora S, et al. - Researchers used invasive coronary angiography (ICA) and intravascular ultrasound (IVUS) to determine the extent and prevalence of asymptomatic coronary artery disease (CAD) in patients with type 2 diabetes. They also investigated the possibility of modulating CAD progression, which was evaluated by ICA via multi-intervention to attenuate cardiovascular (CV) risk. In a 2-year, randomized, controlled study, hospital-based multi-intervention (n = 30) was compared with standard care (n = 26) in 56 diabetic patients with ≥ 1 additional CV risk factor. At baseline, ICA was performed. Both ICA and IVUS were performed at year 7. Angiographic progression of CAD was not affected by a 2-year multi-intervention, despite improvement in CV risk factors. A high prevalence of asymptomatic CAD was noted in diabetic patients, based on IVUS findings. These results, thus, warrant broader residual CV risk management using alternative approaches.