Bae KY, et al. - Researchers investigated how periventricular white matter hyperintensities (PVWMH) and deep white matter hyperintensities (DWMH) impact post-stroke depression (PSD) at two-time points following stroke. They evaluated 408 patients 2 weeks after stroke (baseline) and followed up 284 (70%) of those 1 year later. They obtained magnetic resonance images in all subjects at baseline and rated PVWMHs and DWMHs using the 4-point modified Fazekas scale. Based on DSM-IV criteria, depression was diagnosed; subjects were divided into without PSD, any PSD, and major PSD groups at baseline and follow-up examinations were conducted by the severity of depression. Outcomes revealed that the type of WMH and time after stroke influenced how WMH and PSD associate with each other; early depressive symptoms are associated with PVWMHs and delayed severe depression is associated with DWMHs.