Kim MK, et al. - Researchers investigated if variability in metabolic parameters—fasting blood glucose and cholesterol concentrations, blood pressure, and body weight—has any additive impact on the risk of mortality and cardiovascular outcomes in this study involving the general population. They used nationally representative data from the Korean National Health Insurance System to evaluate 6,748,773 people who were free of diabetes mellitus, hypertension, and dyslipidemia and who had ≥3 health examinations from 2005-2012 and were followed to the end of 2015. They noted that mortality and cardiovascular events were independently predicted by high variability of fasting blood glucose and total cholesterol levels, systolic blood pressure, and body mass index. Also, a graded link was observed between the number of high-variability parameters and cardiovascular outcomes.