Ponte B, et al. - The purpose herein was to investigate the upshot of caffeine on arterial stiffness by analyzing the correlation of urinary excretion of caffeine and its related metabolites with pulse pressure (PP) and pulse wave velocity (PWV). A connection was demonstrated between urinary caffeine, paraxanthine, and theophylline excretions with decreased parameters of arterial stiffness. This data displayed a protective effect of caffeine intake beyond its blood pressure–lowering effect.