Associations of serum nonesterified fatty acids with coronary heart disease mortality and nonfatal myocardial infarction: The CHS (Cardiovascular Health Study) cohort
Journal of the American Heart Association Mar 13, 2021
Huang NK, Bůžková P, Matthan NR, et al. - By analyzing CHS (Cardiovascular Health Study) participants (N = 1,681) with no history of myocardial infarction (MI), angina, or revascularization or were free of MI at baseline (1996–1997), researchers investigated if individual or subclasses (saturated, polyunsaturated [n‐6 and n‐3], and trans fatty acids) of serum nonesterified fatty acids (NEFAs) associate with coronary heart disease (CHD) mortality and nonfatal MI. They employed gas chromatography to quantify NEFAs. A median follow‐up of 11.7 years was performed, during which, occurrence of 266 cases of CHD death and 271 cases of nonfatal MI was documented. Overall, findings revealed a positive association of 2 NEFAs, dihomo‐γ‐linolenic and elaidic acids, with CHD mortality and nonfatal MI, respectively, in CHS participants, indicating potential susceptibility biomarkers for risks of CHD mortality as well as nonfatal MI.
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