Associations of physical activity and β-amyloid with longitudinal cognition and neurodegeneration in clinically normal older adults
JAMA Neurology Oct 26, 2019
Rabin JS, Klein H, Kirn DR, et al. - In this longitudinal observational study of 182 individuals from the Harvard Aging Brain Study, researchers investigated whether physical activity moderated the relationship of β-amyloid (Aβ) burden with longitudinal cognitive drop and neurodegeneration in clinically normal people and explored whether these correlations were independent of vascular risk. A notable interaction of physical activity with Aβ burden such that greater physical activity was related to slower Aβ-related cognitive deterioration and volume loss was observed in models testing Preclinical Alzheimer Cognitive Composite (PACC) decay and volume loss. Adjusting for vascular risk did not remodel these relationships The lower vascular risk was independently correlated with slower Aβ-related PACC deterioration and volume loss in these models. Thus, in asymptomatic people, greater physical activity and lower vascular risk unrestrictedly attenuated the negative relationship of Aβ burden with cognitive deterioration and neurodegeneration. Moreover, these findings imply that on delaying the progression of Alzheimer disease, involving in physical activity and lowering vascular risk may have extra protective influences.
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