Narla S, et al. - Via analyzing data from the 2002–2012 National Inpatient Sample, including a ∼20% sample of all US hospitalizations (n=72,108,077 adults), researchers investigated pemphigus or pemphigoid associations with autoimmune disorders and related adult outcomes. Pemphigus and pemphigoid were linked to ≥1 autoimmune disorder in multivariable logistic regression models. Pemphigus and pemphigoid were correlated in bivariable models with 9 of 29 and 13 or 32 autoimmune disorders. Unspecified autoimmune disease, vitiligo, eosinophilic esophagitis, and myasthenia gravis had the strongest effect-sizes among pemphigus inpatients. While unspecified autoimmune disease, vitiligo, and chronic urticaria had the strongest effect sizes among pemphigoid inpatients. Autoimmune comorbidities by age, sex, and race/ethnicity were significantly different. Investigators found that inpatients with pemphigus or pemphigoid had increased odds of multiple cutaneous, extra-cutaneous and systemic autoimmune disorders, which were linked to a considerable cost-burden. An estimated $2,286,588 and $4,301,681 excess annual hospital care costs were attributed, respectively, to autoimmune disorders among inpatients with pemphigus and pemphigoid.