Wahab RJ, Jaddoe VWV, Roest AAW, et al. - Given that gestational diabetes mellitus was associated with offspring cardiac congenital malformations, ventricular hypertrophy, and diastolic dysfunction in large observational cohort studies and experimental animal models, researchers explored the correlations of maternal random glucose concentrations across the full range with childhood cardiac ventricular structure and function. Maternal random glucose concentrations were measured at a median of 13.1 weeks of gestation in a population-based prospective cohort among 1,959 women and their offspring. Data reported that the mean maternal random glucose concentration was 4.4 mmol/L (SD 0.8). Findings suggested an association of higher maternal random glucose concentrations in the first half of pregnancy with a lower childhood left ventricular mass and left ventricular end-diastolic volume, with the strongest connections for childhood left ventricular mass. Such associations have not been explained by maternal, birth, or childhood characteristics.