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Associations of gestational age and birth anthropometric indicators with brain white matter maturation in full-term neonates

Human Brain Mapping May 10, 2019

Jin C, et al. - The indicators for neonatal assessment include gestational age (GA) and anthropometric measurements (birth weight, crown-heel length, head circumference) but their correlation with the white matter (WM) maturation remains unclear. With this investigation researchers are trying to understand the relationship between the two. Retrospectively 51 full-term neonates (GA range, 37–42 weeks) with no abnormalities on MRI were included. The relationship with the WM maturation and birth assessment was estimated using diffusion tensor imaging (DTI)-metrics (fractional anisotropy, mean diffusivity, axial diffusivity, radial diffusivity), were identified by using DTI tract-based spatial statistics and automated fiber-tract quantification. The results showed higher GA, birth weight, and crown-heel length indicated greater WM maturation in full-term neonates. However, head circumference exhibited a weaker association with WM maturation. GA was one of the most relatable indicators in assessing WM maturation among the four indicators. This study widens the spectrum of knowledge on the relation with neonatal brain development and birth indicators. This may also proves to be a relevant reference for future studies on this subject.
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