Huang T, et al. - Via prospective evaluation of 133,526 women in the Nurses' Health Study (NHS; 1980–2012) and NHSII (1989–2013), researchers assessed the risk of ovarian cancer in relation to early life adiposity and adulthood adiposity using Cox proportional hazards models. For body mass index (BMI) at age 10, at age 18, and for current BMI, the estimated hazard ratio (95% confidence interval) for ovarian cancer risk per 5 kg/m² was 0.84, 1.17, and 1.06, after mutual adjustment for BMI at age 10, BMI at age 18 and current BMI. However, after adjusting for BMI change between age 10 and 18 and BMI change after age 18, a reduction was noted in the inverse link with BMI at age 10. Findings revealed a stronger link between early life changes in adiposity and ovarian cancer risk vs the link between adulthood changes in adiposity and ovarian cancer risk. In general, stronger links were observed for premenopausal cases or non-serous tumors.