Giudici KV, de Souto Barreto P, Guerville F, et al. - Among non-demented, community-dwelling older adults at risk of cognitive decline, who were volunteers from the interventional study Multidomain Alzheimer Preventive Trial, researchers investigated whether low-grade inflammation (LGI) (chronically raised C-reactive protein) and hyperhomocysteinemia (HHcy) were related to variation in intrinsic capacity (IC) domains (mobility, cognition, psychological and vitality) and in a combined IC Z-score during a 5-year observation period. The sample comprised of 1,516 people, aged ≥ 70 years (64.5% female, mean age 75.4 years). After a 5-year follow-up, older adults demonstrated impairment on the combined IC levels in relation to both LGI and HHcy. Following a 5-year follow-up, reduction in IC Z-score was also evident in all groups.