Ma L, Guo W, Yang L, et al. - Using Cox proportional hazard models, researchers evaluated the risk of cardiovascular disease (CVD) in correlation with newly defined blood pressure (BP) classes by the 2017 American College of Cardiology/American Heart Association guideline as well as changes in BP among middle-aged and older Chinese (n = 29,086; aged 61.6 years) from the Dongfeng-Tongji cohort. Findings revealed an increased risk of incident CVD in correlation with newly defined stage 1 hypertension and elevated BP, whereas varying degrees of influences of long-term changes of SBP and DBP on CVD incidence were evident. They observed 43% increased risk for CVD among individuals with maintained stage 1 hypertension vs those with stable BP less than 130/80 mmHg, over a 5-year duration, this was more notable among those age at least 60 years. Results showed 15 and 16% higher CVD risk in relation to an increase in SBP at least 15 mmHg and DBP at least 5 mmHg vs stable BP (−5 to 5 mmHg); whereas CVD and coronary heart disease risk attenuated 25 and 22% with a reduction in SBP greater than 15 mmHg, but not with DBP.