Longobardi L, et al. - Researchers evaluated the relationship between chemokine-ligand-2 (CCL2) serum concentrations at baseline and knee radiographic OA (knee-rOA), knee-rOA progression, individual radiographic features and knee symptomatic OA at 5-year follow-up. Findings suggested that in order to elucidate some mechanisms of joint destruction and identify individuals with higher odds of structural knee changes, serum CCL2 could help. Experts noted a significant association of continuous log-CCL2 with knee-rOA. Significant linear associations of CCL2 tertiles with presence and progression of knee-rOA and medial joint space narrowing were seen, but not with presence or progression of osteophytes, bone sclerosis, knee symptoms, or symptomatic knee-rOA.