Szymkowicz SM, et al. - In a sample of middle-aged to older adults, researchers investigated the extent to which depressive symptoms were related to brain volumes in fronto-limbic structures. As per findings, greater symptomatology was observed with smaller volume in limbic brain regions. They gained evidence for preclinical biological markers of major depression and specifically advance knowledge of the relationship between subclinical depressive symptoms and brain volume. Importantly, variations by specific depressive symptom subscales were noticed, which suggested a symptom-differential relationship between subclinical depression and brain volume alterations in middle-aged and older individuals.