Yeh JJ, et al. - Among retrospectively enrolled patients with asthma–chronic obstructive pulmonary disease overlap syndrome (ACOS), researchers investigated how coronary artery disease (CAD) and stroke risks may be influenced by statin use. Overall, 916 patients received statins and 6,338 did not. The investigators used time-dependent Cox proportional regression to determine the cumulative incidence of CAD and stroke (ischemic and hemorrhagic). Sex, age, comorbidities, inhaled corticosteroid steroid (ICS) use, and oral steroid (OS) use were adjusted. All statin users demonstrated a lower CAD risk, irrespective of the duration of use. Only long-term statin users had a lower ischemic stroke risk. The authors concluded that statin use was not related to hemorrhagic stroke risk.