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Associations between sleep apnea and subclinical carotid atherosclerosis: The Multi-Ethnic Study of Atherosclerosis

Stroke Oct 31, 2019

Zhao YY, Javaheri S, Wang R, et al. - Researchers used multivariable linear and logistic regression models to explore the connections of snoring and several measurements of sleep apnea (SA) with subclinical carotid atherosclerosis in a large multiethnic population sample. The sample included 1,615 candidates (mean age was 68 years) from examination 5 (2010–2013) of the MESA study (Multi-Ethnic Study of Atherosclerosis). Utilizing high-resolution B-mode ultrasound, carotid atherosclerosis was measured. Among younger but not older people, greater hypoxemia was related to increased carotid intima-media thickness. Greater hypoxemia was linked to increased carotid intima-media thickness in blacks in evaluating race-specific outcomes. An association was found between sleep disturbances and subclinical carotid atherosclerosis in both men and women, especially in those < 68 years of age. For carotid plaque and carotid intima-media thickness, the mechanisms underlying the link between SA and carotid atherosclerosis can differ.
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