Bae SC, et al. - Meta-analyses of paraoxonase-1 levels and Q192R and L55M and polymorphisms in SLE were carried out and nine articles were included in order to investigate correlations between paraoxonase-1 levels, gene polymorphisms and SLE. Ethnicity-specific meta-analysis exhibited a correlation tendency between reduced paraoxonase-1 activity and lupus in Europeans. In SLE in a single Arab and African population, paraoxonase-1 activity was decreased. Reduced paraoxonase-1 activity was discovered in a small sample of SLE individuals. Ethnicity-specific analysis symbolized a correlation between the paraoxonase-1 55 M allele in the Arab SLE population. Nevertheless, a lack of correlation with SLE and the paraoxonase-1 192 R allele was noted. Meta-analyses exhibited decreased paraoxonase-1 activity in individuals with SLE and discovered potential correlations between SLE and paraoxonase-1 L55M polymorphism in a specific ethnic group.