Williams AM, et al. - There is a lack of studies assessing the role of increased chronic inflammation in the development of cancer-related cognitive impairment (CRCI) associated with chemotherapy. The initial findings supported the hypothesis that soluble tumor necrosis factor receptor I (sTNFRI) is involved in CRCI, because a significant association was obvious between higher sTNFRI and lower scores on the short-term visual memory delayed match to sample test in breast cancer patients receiving chemotherapy.