McGee EE, et al. - Using Surveillance, Epidemiology, and End Results (SEER)-Medicare data (1992-2013), researchers conducted a population-based, case-control study investigating the associations between autoimmune conditions and hepatobiliary cancers among adults aged ≥66 in the United States. They used multivariate logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for associations with 39 autoimmune conditions identified via Medicare claims. Outcomes suggest the association of 16 conditions with at least one hepatobiliary cancer. The strongest risk estimates were for primary biliary cholangitis with hepatocellular carcinoma and primary sclerosing cholangitis with intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, gallbladder cancer, and ampulla of Vater cancer. Findings thereby support a shared immuno-inflammatory etiology to these cancers.