Chang HP, et al. - In this two-cohort study, researchers evaluated single nucleotide polymorphisms (SNPs) in the insulin-like growth factor (IGF)-1, IGF-2, IGF-3, IGF-1 receptor (IGF1R), IGF-2 receptor (IGF2R), and IGF -binding protein 3 (IGFBP-3) genes, and their relationship with demographics and metabolic proteins in ≤8-year-old girls with central precocious puberty (CPP). Regardless of adjustment for body mass index (BMI), the IGF-1 serum levels of the CPP group showed a higher association with bone age, z-scores of height and weight, and luteinizing hormone than those of the control group. It was noted that height in the CPP group was related to IGF-2(3580), but not the z-score of the height. Findings suggested a significant relationship of weight and BMI with the combination of [IGF-2(3580) + IGF2R + IGFBP-3] in the CPP group. Results of this study indicate that these known SNPs of these IGF-1 axis genes seem to play minor roles in the risk for CPP development.