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Association of vitamin D and parathyroid hormone with Barrett’s esophagus

Journal of Clinical Gastroenterology Apr 10, 2019

Rubenstein JH, et al. - Because esophageal adenocarcinoma was inversely linked with ultraviolet radiation exposure, possibly due to vitamin D deficiency or hyperparathyroidism furthering gastroesophageal reflux disease (GERD) and Barrett's esophagus, researchers determined the correlation between parathyroid hormone (PTH) and vitamin D deficiency with GERD symptoms, erosive esophagitis, and Barrett’s esophagus. Sera from 605 men, including 150 with GERD, 216 with erosive esophagitis, 145 with Barrett's esophagus, and 174 ordinary patients were tested. An inverse connection was found between serum PTH and Barrett’s esophagus. No link was found between vitamin D deficiency or hyperparathyroidism with GERD symptoms or erosive esophagitis.

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