Kim J, et al. - In this cohort study of 48,400 US men (mean [SD] age, 54.3 [9.9] years) and 75,170 US women (mean [SD] age, 50.4 [7.2] years), researchers ascertained if vitamin A intake is correlated with a decline in squamous cell carcinoma (SCC) risk. They analyzed the intake of vitamin A and carotenoids and SCC risk in the Nurses’ Health Study (1984-2012) and the Health Professionals Follow-up Study (1986-2012). Higher total vitamin A intake was linked to a decrease in cutaneous SCC risk during a follow-up period of more than 26 years. Findings revealed that there was an inverse connection between intake of vitamin A and carotenoids and the risk of cutaneous SCC, promoting the protective role of vitamin A against the development of SCC. Future studies are required to determine if supplementation with vitamin A plays a part in SCC chemoprevention.