Abdelghany AA, Toraih EA, Mohamed AA, et al. - In this preliminary prospective case-controlled study, researchers sought to examine the correlation of angiogenesis-inducer vascular endothelial growth factor (VEGF) gene family and related receptor variants (rs833069, rs12366035, rs7664413, rs7993418, and rs2305948) with susceptibility of diabetic retinopathy (DR) and the response to one dose of aflibercept treatment in type 2 diabetes mellitus (T2DM). The sample consisted of consecutive eligible patients with T2DM (n = 125) and 110 unrelated controls. Polymorphisms of the VEGF/receptor studies could be considered as genetic risk factors for the development of DM/DR and could play an important role in aflibercept early response for DR patients in the study population.