Ascher SB, et al. - Given the association of tenofovir disoproxil fumarate (tenofovir) with elevated concentrations of biomarkers of kidney damage and dysfunction in individuals with HIV, researchers investigated how these kidney biomarkers are related with longitudinal kidney function decline. In this Multicenter AIDS Cohort Study and Women’s Interagency HIV Study, 14 urinary biomarkers of kidney injury were evaluated for their association with changes in eGFR among 198 men and women with HIV who initiated tenofovir between 2009 and 2015. In individuals with HIV, higher pre-tenofovir clusterin and kidney injury molecule-1, lower pre-tenofovir uromodulin, and higher year 1 IL-18 were jointly associated with larger eGFR declines.