Lee DH, et al. - Researchers used cross-sectional data to determine the impact of specific components of physical activity (volume, type and intensity), and their impact on adiposity and diet, on cancer-related biomarkers. They analyzed data on C-reactive protein (CRP), interleukin 6 (IL6), tumor necrosis factor α receptor 2 (TNFαR2), adiponectin, C-peptide and triglycerides/high-density lipoprotein cholesterol ratio (TG/HDL) from 7,219 men in the Health Professionals Follow-up Study (1992-1994). These patients were queried using questionnaires for information regarding physical activity, diet and adiposity. Using multivariable-adjusted linear regression analyses, relative concentrations of biomarkers by physical activity were calculated. Findings revealed favorable cancer-related biomarkers in association with high physical activity, preferably aerobic plus resistance training. The percent relative difference in concentration of biomarkers was -31% for CRP, -22% for IL6, -8% for TNFαR2, +9% for adiponectin, -22% for C-peptide, and -20% for TG/HDL, when comparisons were made between the highest (63+ metabolic equivalent (MET)-hours/week) and the lowest (0 to 9 MET-hours/week) physical activity groups.