Zhang N, Xiang Y, Zhao Y, et al. - Given important roles of triglyceride-glucose index (TyG) and high-sensitivity C-reactive protein (hsCRP) in the pathophysiological mechanisms of atherogenesis have been reported, researchers here attempted to determine the cumulative value of TyG and hsCRP in detecting asymptomatic intracranial arterial stenosis (aICAS), as well as its severity and numerical burden. Total 1,938 participants aged ≥40 years were included. Post-adjustment for conventional confounders, an independent association of the following with moderate-to-severe aICAS was revealed: isolated high-hsCRP, isolated high-TyG, and high-TyG combined with high-hsCRP. A 2.6 times higher odds ratio (OR) of having a single moderate-to-severe aICAS as well as a 3.3 times higher OR of having multiple moderate-to-severe aICASs was found in participants with high-TyG and high-hsCRP vs the low-TyG and low-hsCRP group. Overall, findings indicate that a better identification of moderate-to-severe aICAS as well as of its numerical burden may be offered by cumulative value of TyG and hsCRP.