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Association of total and differential leukocyte counts with cardiovascular disease and mortality in the UK Biobank

Journal American Heart Association Jun 25, 2018

Welsh C, et al. - Researchers investigated a possible association of specific leukocyte subpopulations with cardiovascular disease (CVD) among participants (478,259) from UK Biobank with data for white blood cell count. During a median follow-up of 7 years, the occurrence of death attributed to CVD and non-CVD causes was reported. Using the fifth decile as the referent group in Cox models, assessment of deciles of leukocyte counts (lymphocytes, monocytes, neutrophils, eosinophils, and basophils) was performed. In the sensitivity analysis, participants with baseline comorbidites and the first 2 years of follow-up were not included. They found that among circulating leukocyte subpopulations, the most consistent link was the one observed between neutrophil count in men and fatal and nonfatal CVD.

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