Cuna A, Lagatta JM, Savani RC, et al. - A higher probability of Grade 2 or 3 bronchopulmonary dysplasia (BPD) development was associated with later initiation of treatment with systemic corticosteroids in preterm infants in routine clinical practice, vs earlier administration of systemic corticosteroids.

• A multi-center retrospective cohort study.

• Children's Hospitals Neonatal Database and Pediatric Health Information System database were used.

• Participants were preterm infants <32 weeks' gestation who were given systemic corticosteroids after 7 days of age and before 34 weeks' postmenstrual age.

• When birth features, admission characteristics, center, and co-morbidities were adjusted, higher independent odds of developing Grade 2 or 3 BPD were noted in infants first treated at 36-49 days and >50 days vs those treated at 8–21 days.