Wang JC, et al. - Researchers analyzed previous studies assessing the chronic rhinosinusitis (CRS) microbiome in relation to clinical results, via a systematic review. Overall 9 studies with 244 CRS patients were identified from PubMed/Medline, Cochrane, and EMBASE. In 8 studies, 16s–ribosomal RNA (16s-rRNA) gene sequencing was applied to evaluate the sinonasal microbiome, and in one study, 16s-rRNA PhyloChip analysis was used. In 3 studies, better surgical outcome was predicted by baseline abundance of phylum Actinobacteria (specifically genus Corynebacterium). A positive correlation of C. tuberculostearicum with symptom severity was revealed in one study. In one study, it was shown that Acinetobacter johnsonii was related to improvement in symptom scores and that Pseudomonas aeruginosa negatively influenced the quality of life. Findings revealed that microbiome data are varied in their link with clinical results of CRS patients.