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Association of T helper 1 cytokine gene single nucleotide polymorphisms with ulcerative colitis and Crohn’s disease

Digestive Diseases Aug 27, 2018

Ebrahimi Daryani N, et al. - Authors investigated whether there was a connection between T helper type 1 (Th1) cytokine polymorphisms (interferon gamma [IFN-γ] +874 A/T, interleukin-12 [IL-12] –1188 A/C, IL-2 –330 G/T, IL-2 +166 G/T) and susceptibility to and clinical features of inflammatory bowel disease (IBD) by analyzing data of 75 IBD patients (40 Crohn’s disease [CD] patients and 35 ulcerative colitis [UC] patients) and 140 healthy controls. Researchers, for the first time, reported significant correlations between single nucleotide polymorphisms (SNPs) within the interferon gamma [IFN-γ] and IL-2 genes and IBD.
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