Rajan S, McKee M, Rangarajan S, et al. - Researchers examined if there is variation across and within countries concerning the increased risk of incident cardiovascular disease and mortality in middle-aged adults with depressive symptoms. They conducted a multicenter, population-based cohort study of 145,862 participants between January 2005 and June 2019 (median follow-up, 9.3 years); the participants were from 370 urban and 314 rural communities from 21 economically diverse countries on 5 continents. Observations suggest that the risk of cardiovascular events and death increased by 20% in people with four or more depressive symptoms vs people without symptoms. They indicated that there was increase in the relative risk at all economic levels but it was more than twice as high in urban vs rural areas.