Song L, Qiao S, Guan C, et al. - To assess the link of less‐certain indication of chronic total occlusion percutaneous coronary intervention (CTO‐PCI) with subsequent clinical results, this study was undertaken with patients receiving CTO‐PCI at a large‐volume single center between 2010 and 2013. Five‐year composite endpoint of death or myocardial infarction (MI) was assessed as a primary outcome. Findings of this large cohort of CTO‐PCI revealed a higher risk of long‐term mortality or MI in relation to those who were asymptomatic, non‐viable myocardium in the CTO territory, or deemed more favorable for coronary artery bypass grafting.