MacKay JW, et al. - This nested case-control study inspected if the initial or 12–18-month change in magnetic resonance imaging (MRI) subchondral bone texture was predictive of radiographic knee osteoarthritis (OA) progression over 36 months. Enrollees belonged to the Osteoarthritis Initiative (OAI) Bone Ancillary Study, who underwent MRI optimised for subchondral bone assessment at either the 30- or 36-month and 48-month OAI visits. Findings unveiled that the initial and 12–18-month changes in MRI subchondral bone texture score were prominently related to radiographic progression at 36 months. It displayed better predictive performance for 12–18-month change in texture. Therefore, it was deduced that texture analysis could be a beneficial biomarker of subchondral bone in OA.