Jafari A, de Lima Xavier L, Bernstein JD, et al. - In this case-control study involving 22 patients with chronic rhinosinusitis and 22 healthy controls, researchers intended to determine if there is an association between sinonasal inflammation and functional brain connectivity (Fc), which may underlie chronic rhinosinusitis–related cognitive changes. According to findings, participants with sinonasal inflammation had lower brain connectivity within a major functional hub that plays a key role in cognition modulation. This region is also more connected to areas activated during introspective and self-referential processing and less connected to areas involved in detection and response to stimuli. Future prospective studies are needed to determine whether these findings are applicable to a clinical chronic rhinosinusitis population. This study provides initial evidence for changes in functional brain connectivity as a possible basis for cognitive dysfunction seen in patients with chronic rhinosinusitis.